Hong Kong researchers found that individuals with HLA-B*7303 gene
type have much higher risk of getting Severe Acute Respiratory
Syndrome (SARS) while those with HLA-DRB1*0131 gene type have much
lower risk than the general population.
The Chinese University announced the findings at a press conference
Thursday, saying the findings will lead to better understanding of
the disease mechanisms of SARS and could help design the SARS
prevention programs.
The study was made on 90 serologically confirmed Chinese SARS
patients who had been treated in some Hong Kong hospitals when SARS
prevailed in Hong Kong in the first half of last year.
The researchers made DNA based HLA gene typing on those 90 patients
and compared the frequencies of HLA genes between SARS patients and
the general Hong Kong Chinese population.
Researchers said the findings may also help explain why none of the
staff of a Hong Kong hotel but only some residents contracted with
SARS in mid-March last year and many staff, students of the Prince
of Wales Hospital attached to the university did not have SARS even
after prolonged exposure and family members in the same household
units differentially affected in Amoy Garden, where SARS hit quite
a number of residents.
SARS infected more than 1,700 people and claimed 299 lives in Hong
Kong in the first half of 2003 and Hong Kong has been keeping
vigilance on SARS prevention since then.
(Xinhua News Agency January 15, 2004)
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